There's a game called Pandemic 2 I recently played it and thought it was actually really realistic. The only thing was that If an island shut down its ports then their was no physical way to infect that island which I thought wasn’t that realistic because most Islands would have to depend on foreign imports for something, but the overall realistically was cool because your disease had a visibility bar which means certain mutations caused your disease to become easier to spot. The cure for your disease can also backfire making your disease immune to all cures.
http://pandemic3.com/pandemic3.swf
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